Covid Vaccine

The Problem of Antibody-Dependent Enhancement

Calvin Luther Martin, PhD*

Calvin Luther Martin, PhD*

January 27, 2021

I have several years of graduate training in immunology/molecular biology. In the 1980s, I was enrolled in the PhD program in immunology at the Waksman Institute of Microbiology at Rutgers University. I didn’t complete the PhD in immunology because it interfered too much with my being, simultaneously, a Professor of History at Rutgers.  (My PhD is in history with a subfield in anthropology from the University of California.)

A word of caution

Antibody-Dependent Enhancement

Before getting the vaccine, be sure you are aware of an immunopathology (immune disease) called “antibody-dependent enhancement.”

Definition and Explanation:

In reacting either to an infection or a vaccine, your body makes antibodies of various types to a variety of proteins on the surface of the virus. Some of the antibodies will be neutralizing, meaning that when they bind to the virus they prevent the virus from getting inside human cells. Other antibodies can likewise bind to the virus, but not make any difference to the virus’s successful functioning. These are non-neutralizing antibodies.

The problem is that both types of antibodies can also bind with loose viral proteins, especially from a vaccine, or a subsequent exposure to another virus, or with proteins of similar shape on or in human cells themselves. When antibodies bind to a loose protein, this triggers what’s called an immune complex reaction.

Immune complexes tend to deposit in certain parts of the body, such as the joints and kidneys. Antibody-Dependent Enhancement (ADE) appears to be a damaging inflammatory reaction of one’s own antibodies against one’s own tissues or cells, again, provoked by antibodies binding to one’s tissues or by immune complexes being deposited.

The antibody/antigen reaction triggers other inflammatory cells in a cascade effect, leading to tissue and organ damage which can be very serious.

The two articles, below, warn of Antibody-Dependent Enhancement from the Covid vaccine. Both were published in credible, peer-reviewed science and clinical journals within the past 3 to 4 months.  The credentials of the authors are impeccable.  I have highlighted passages in both articles. (Scroll to the end of the second article to see my highlighting therein.)

Before you get the Covid vaccine, you would be wise to discuss Antibody-Dependent Enhancement with your physician.

The International Jour. of Clinical Practice
The International Jour. of Infectious Diseases

11 thoughts on “Covid Vaccine: The Problem of Antibody-Dependent Enhancement”

  1. Avatar

    I want to know the truth about the use of hydroxychloroquine as a preventative, as Dr. Fauci said in his article for the Virology Journal in 2005. Why did he ridicule President Trump for seeing clear benefits of using this as a preventative in March 2020? And has the FDA quietly re-authorized the use of HCQ as a preventative and HCQ cocktail with zinc Azithromycin?

    Is Dr. Fauci compromised by a monetary interest in the pharmaceutical companies manufacturing these vaccines?

  2. Avatar
    Carmel McCormack (Ireland)

    Leading pro-vaccine scientist, Geert Vanden Bossche, calls for global, mass Covid vaccinations to be stopped immediately.

    Geert Vanden Bossche Interview on The Highwire
    Published on Mar 12, 2021
    Mass Vaccination in a Pandemic – Benefits versus Risks – Interview with Geert Vanden Bossche

    Published on Mar 17, 2021
    SARS-CoV-2, Vaccination & Early Ambulatory Treatment – a Webinar with Geert Vanden Bossche, DVM, PHD, & Peter McCullough, MD, MPH.

    See important article and related comments

  3. Avatar

    ‘Cardozo and Veazy then show how informed consent forms for volunteer subjects in vaccine trials fail to meet the required ethical standards for informed consent. While ADE is mentioned, it is generally added at the end of the list of possible risks and its implications and identification are unlikely to be adequately understood by the lay public.

    With a tick in the box and a sense from regulators and vaccine makers that they’ve successfully negotiated the hurdle of ADE/VAH risks, there’s been no further discussion of the issue. The vast majority of pre-vaccinees lining up as part of the global mass vaccination roll out simply have no idea of the risk — because they’re not being told.’

    ‘Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus’

    ‘Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.’

  4. Avatar
    Carmel McCormack (Ireland)

    ‘….anyone with an inflammatory disease, like rheumatoid arthritis, Parkinson’s disease, chronic Lyme disease, anybody with an acquired immune deficiency from any pathogens and environmental toxins.

    Those are the people who will be killed, murdered, by this vaccine…’

    ‘….others who are at high risk from these COVID-19 gene therapies include those who have gotten seasonal influenza vaccines, Blacks and Hispanics. Blacks and Hispanics are particularly at risk for antibody-dependent immune enhancement, in particular, due to genetics. Tragically, these vaccines are given to the most susceptible under the guise of racial and social justice.’

    ‘….the World Health Organization is now saying pregnant women should not get the Moderna or Pfizer vaccines due to reports of late-term miscarriages…’

    Also read in this article about what to do if you got the vaccine and are having problems.

  5. Avatar

    Being our own advocates in this society is a daunting task, second only to advocating for our family/children.

    Speaking from years of health issues related to autoimmune issues, allergies, and the accompanying health problems, I know that many in the medical field are ignorant of whole health. Unfortunately, they are out of their element when it comes to many of the ailments that plague our population.

    With the growing number of infections from tick-borne disease, chemical exposure, medicine-induced illness, and the myriad other issues reducing the health of the population, it seems nearly impossible for a physician to “heal” a patient.

    Now, adding to the confusion, we have Covid and the ridiculous policies governing testing and treating, and the co-called vaccine. The population is not ready for the vaccine, we are not fully informed, we do not understand how this shot/series of shots will impact our health, long-term. Despite the numerous studies demonstrating a lack of evidence that these vaccines are safe, never mind able to illicit a proper immure response resulting in immunity to anything, we are plunging ahead. Everyone and their grandmother will be getting these vaccines, possibly mandated to do so, regardless of one’s health profile, genetic makeup, etc.

    This year we will see in real time how medicine has been manipulated, distorted, and perverted for the profit of corporations and government control of the population. In the years to come autoimmunity will skyrocket, longevity decrease, and mental illness increase. These ramifications are the result of a society of uniformed consumers.

    I pray we are given the choice to be simply observers.

  6. Avatar
    Carmel McCormack (Ireland)

    ‘The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved product, MODERNA COVID-19 VACCINE,..’

    There is no information on the co-administration of the Moderna COVID-19 Vaccine with other vaccines.’

    See Fact-sheet-providers-Moderna COVID-19 vaccine.pdf

    ‘The Moderna COVID?19 Vaccine has not been approved or licensed by the US Food and Drug Administration (FDA), but has been authorized for emergency use by FDA, under an Emergency Use Authorization (EUA), to prevent Coronavirus Disease 2019 (COVID?19) for use in individuals 18 years of age and older. There is no FDA-approved vaccine to prevent COVID?19.’


    ‘The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to permit the emergency use of the unapproved product, Pfizer-BioNTech COVID-19 Vaccine, for active immunization to prevent COVID-19 in individuals 16 years of age and older.’

    ‘Use with Other Vaccines
    There is no information on the co-administration of the Pfizer-BioNTech COVID-19 Vaccine with other vaccines.’

    There is no approved alternative vaccine to prevent COVID-19. There may be clinical trials or availability under EUA of other COVID-19 vaccines.’

    ‘Global Information About Pfizer?BioNTech COVID?19 Vaccine (also known as BNT162b2)

    The approval status of the Pfizer?BioNTech COVID?19 Vaccine varies worldwide. In countries where the vaccine has not been approved by the relevant regulatory authority, it is an investigational drug, and its safety and efficacy have not been established.’

    United States

    ‘The Pfizer-BioNTech COVID-19 Vaccine has not been approved or licensed by FDA, but has been authorised for emergency use by FDA under an Emergency Use Authorization to prevent Corona Virus Disease 2019 COVID-19 for use in individuals 16 years of age and older. The emergency use of this product is only authorized for the duration of the declaration that circumstances exist justifying the authorization of emergency use of the medical product under Section 564(b)(1) of the FD&C Act unless the declaration is terminated or authorization revoked sooner.’

    ‘The Pfizer-BioNTech COVID-19Vaccine may not protect all vaccine recipients

    In clinical studies, adverse reactions in participants 16 years of age and older included pain at the injection site (84.1%), fatigue (62.9%), headache (55.1%), muscle pain (38.3%), chills (31.9%), joint pain (23.6%), fever (14.2%), injection site swelling (10.5%), injection site redness (9.5%), nausea (1.1%), malaise (0.5%), and lymphadenopathy (0.3%)

    Severe allergic reactions have been reported following the Pfizer-BioNTechCOVID-19 Vaccine during mass vaccination outside of clinical trials. Additional adverse reactions, some of which may be serious, may become apparent with more widespread use of the Pfizer-BioNTech COVID-19 Vaccine’

  7. Avatar
    Carmel McCormack (Ireland)

    The inbuilt links to the Analysis and the Form within the following Docs4OpenDebate document failed to display when posted earlier.
    Please see links to the Analysis and the Form below.

    Here you will find an analysis of the covid-19 vaccines approved in Belgium with regard to their side effects and efficacy, and of the physician’s liability. This document is addressed to medical doctors, but also provides you with all the information available on this moment.
    And here is a form that you can submit to the doctor administering the vaccine for signature after he or she has read the first document. Both documents therefore belong together.

    Note the ‘Analysis’ and the ‘Form’ are a joint document.

    Docs4OpenDebate Analysis

    Docs4OpenDebate Form for signing by doctors administering the covid vaccines

  8. Avatar
    Carmel McCormack (Ireland)

    ‘There are many studies that demonstrate that ADE is a persistent problem with coronaviruses in general, and in particular, with SARS-related viruses. ADE has proven to be a serious challenge with coronavirus vaccines, and this is the primary reason many of such vaccines have failed in early in-vitro or animal trials.’ (Docs4opendebate 28th January 2021)

    Here you will find an analysis of the covid-19 vaccines approved in Belgium with regard to their side effects and efficacy, and of the physician’s liability. This document is addressed to medical doctors, but also provides you with all the information available on this moment.
    And here is a form that you can submit to the doctor administering the vaccine for signature after he or she has read the first document. Both documents therefore belong together. (Docs4openbate)

    ‘Earlier this month, Dr. Anthony Fauci, chief White House COVID-19 medical advisor, advised people already confirmed to have been infected by SARS-CoV-2 not to get vaccinated within three months of getting the virus. His recommendations have been challenged by other officials, who have said that people can be vaccinated as soon as a vaccine becomes available.’

    ‘Dr. Fauci says he believes waiting the 90 days would prevent interference between natural antibodies and the vaccine.’

    ‘When it comes to the new vaccines, Dr. Merrit, former president of the Association of American Physicians and Surgeons (AAPS) and former military doctor who studied biological warfare, goes through previous animal studies on the technology and paints a dire picture. However, even though modern medical schools do not often teach it, there are ways to treat viral infections that are time-tested and effective, she concludes.’
    Download video here:

    Ask The Experts (Covid-19 Vaccine)

    Make sure you’re sitting down to watch this and that you have a rescue remedy to hand. Examining the “10 Stages of Genocide” created by the American genocide scholar Gregory H Stanton, we come to see the horrific conditions from the past dictatorships reflected right in front of our faces. We are on a path to global genocide.

  9. Avatar

    Thank you for this article, Calvin!

    I have been having a mental debate for a couple weeks about taking the COVID-19 vaccine or not. I have leaned on the side of caution, waiting to see what issues arise from this inoculation.

    This article makes me believe that, perhaps, I am making the right decision to hold off from taking this vaccine.

    Ya know…I can usually deal with misinformation with a bit of armchair research. However, no easily attainable or non-conveyance of information from our elected officials or medical community just pisses me off.

    So, again, thank you for your research and keeping me “in the loop.” I will pass this along to some friends and family.



  10. Avatar
    Carmel McCormack (Ireland)

    Have you noticed how so many deaths have been registered on death certificates as having been caused by COVID-19, yet many of the deaths following COVID-19 vaccines are explained away as old age by virtue that the person vaccinated had reached or gone beyond life expectancy, or the deaths were caused by existing, serious co-morbidities, or the cause was COVID-19, or that the deaths were merely a coincidence?

    Robert F. Kennedy recently said something along the lines that there are now far too many coincidences for it to be put down purely to coincidence!

  11. Avatar

    Great articles! Thank you. We must be an informed public to make sound personal health choices. More now than ever; it is scary and dangerous that “facts” depend on the agenda being driven.

    Funny how temporal associations are always considered “proof” and causal, never a coincidence regarding AGW (Anthropogenic Global Warming)–fossil fuels, CO2, increased global temps–even though there are too many known and unknown variables to honestly make that unequivocal assumption.

    But in reverse and in sharp contrast, temporal associations between vaccination and side effects are almost never considered causal but coincidental.

    It’s concerning that the AMA reports that only 1% of adverse vaccine reactions get reported. How can a true benefit/risk ratio be established with under-reporting?

    When my perfectly healthy infant son had an (afebrile) seizure 6 hours after his 1st vaccine series, the doctor refused to believe it was from the vaccines. I had to report it to the Vaccine Adverse Event Reporting System (VAERS) myself. My son’s neurologist said he should never have another DPT vaccination. My son’s kindly but misinformed pediatrician still wanted him to receive another DPT vaccination. (I said, “Over my dead body!”) Several years later, the original whole-cell DPT version was pulled from the market due to many neurological side effects, and replaced with the current acellular DPT vaccine.

    As a registered nurse for almost forty years, I often witnessed the hospital’s medical community deny the most obvious drug-induced side effects. Their answer was usually NOT to discontinue or substitute for the problem drug, but to add more.

    One of the reasons I wanted out of nursing is that I did not want to be part of that sickness-inducing culture, but sought prevention-oriented and a more holistic approach to healthcare. I started to feel like I was poisoning people instead of actually helping or getting to the root problem and promoting good health.

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